|Introduction: Human papillomavirus (HPV) is a necessary cause of cervical cancer and is associated with other cancers including oropharyngeal and penile cancer. We designed a multipronged campaign to promote informed decision making regarding HPV vaccination in Tarrant County. Outreach targeted to the public occurred through community presentations and billboards. Facebook was used for vaccine information dissemination and as a conduit for answering questions from presentations. Primary care clinics were provided with culturally competent education materials to encourage patient-provider dialogue regarding the vaccine. Methods: In 2012, four focus groups were conducted with 29 staff members from primary care clinics participating in our program. Surveys assessing knowledge, awareness, and perceptions of the HPV vaccine were conducted with 150 parents of children eligible to receive the vaccine before and one year after the campaign was implemented. Chi-square tests were used to assess differences in pre-/post survey results and qualitative analyses were conducted to explore focus group findings. Results: Through different efforts, we established a brand that acknowledges the myths while stressing facts about the HPV vaccine. Among surveyed parents, all HPV and HPV vaccine knowledge measures improved over this 1-year period excluding perceived effectiveness, which showed a 1% reduction in correct responses. Statistically significant improvements among parents were noted in two knowledge measures and in all vaccine uptake variables. Parents reporting discussing the vaccine with providers doubled. Reported receipt of the vaccine increased more than fivefold, and intention to vaccinate rose by more than 12%. Focus groups with providers showed wide diversity in knowledge and attitudes about vaccine among health care providers. Conclusion: There is continued need for education of health care providers at multiple levels. Our clinical inreach campaign resulted in significant improvement of knowledge and attitudes as well as uptake of the vaccine, but these levels require continued improvement. There are significant barriers from misinformation about the vaccine to community collaboration with respected groups. Parental understanding of HPV vaccine benefits and community partnerships play pivotal roles in enhancing awareness and knowledge. Further evaluation of the effectiveness of a social media HPV vaccine awareness campaign using key performance indicators and metrics is necessary.