|Introduction: While cancer rates in rural and urban areas are similar, those living in rural Texas are found with more advanced cancer at the time of diagnosis. Therefore, it is critical for rural physicians to be up-to-date with the most recent knowledge about cancer screening guidelines and be prepared to offer prevention to patients at every opportunity. To address these needs, this project aimed to (1) distribute a developed educational evidence-based DVD on cancer screening guidelines to rural physicians practicing in cluster regions with high cancer rates in Texas, and (2) impact cancer screening behavior of physicians in the proposed rural Texas regions by providing the educational DVD on cancer screening guidelines. Methods: A developed 1-hour DVD with evidence-based lectures on seven cancer screening guidelines delivered by respected Texas specialists was mailed to 2458 rural physicians practicing in high-risk cancer cluster regions in Texas. The seven lectures include cancer screening guidelines for the following cancers: breast, colorectal, lung, skin, cervical and ovarian, and prostate. The 78 Texas counties included in the mail-out are Health Professional Shortage Areas (HPSAs) in high-risk cluster areas for one of the cancers that are lectured in the DVD. The evaluation component of the program utilizes 12 rural clinics that are affiliated with the Rural Osteopathic Medical Education (ROME) program at the UNT Health Science Center at Fort Worth to assess changes in knowledge, attitudes, and practices of physicians using a developed pre-post questionnaire and 750 medical chart reviews. Results: Of the 2458 DVDs that were sent out in May 2011, 2405 DVDs were delivered to physicians practicing in high-risk cancer cluster regions in Texas. Thirteen physicians completed the consent process and the pre- and post-test portion of the study. Analysis of the pre-post surveys indicate a change in skin cancer screening (p=0.007) and ovarian cancer screening beliefs (p=0.03). Conclusion: The program offers to bring evidence-based education using a DVD format to rural physicians specifically practicing in high-risk cancer cluster regions in Texas. This extends to 78 counties in Texas and approximately 2,500 physicians, thus impacting the populations they serve. Chart reviews are currently in progress to evaluate physician cancer screening practices and intermediate study outcomes.